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NSIM lab

Publications

Seung Woo Hong, Junhyung Kim, Jinu Rim, Jung Woo Yu, Hyun Ho Jung, Jong Hee Chang, Won Hee Lee, Won Seok Chang. (2026). Two-Week Interval Hypofractionated Stereotactic Radiosurgery for Benign Intracranial Tumors: Volumetric Kinetics and Radiobiological Rationale. Cancers, Vol.18(4): 617

Han Bi Ji, Jae Hoon Han, Chang Hee Min, Junwon Park, Kyeonggu Lee, Soo Bin Yoon, Eun Jung Kwon, Cho Rim Kim, Min Ji Kim, Myong Ju Kim, Sangheon Han, Chin Su Koh, Sangjun Lee, Jimin Park, Chang-Hwan Im, Won Seok Chang, Young Bin Choy. (2026). Infusion and iontophoresis for directional delivery of compounds to the brain. JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, Vol.153: 718-728

So Young Ji, Young-Hoon Kim, Won Seok Chang, Ho Kang, Jung-Il Lee, Jung Ho Han, Chae-Yong Kim, Jong Hyun Kim, Hae Won Roh, Jeong-Hyun Hwang, Seong-Hyun Park, Young-Cho Koh, Joon Cho, Seok Keun Choi, Chang Kyu Park, Se-Hyuk Kim, Tae Hoon Roh, Sang Ryul Lee, Sang-Won Lee, Soon-Ki Sung, Moo Seong Kim, Won Hee Lee, Sun-Il Lee, Seon-Hwan Kim, Sae Hun Kim, Kyung Hwan Kim, Jung-Won Choi, Ho Jun Seol, Young Hyun Cho, Junhyung Kim, Hyun Ho Jung, Jong Hee Chang. (2026). Tumor Control After Radiosurgery in Sporadic and Neurofibromatosis Type 2 Vestibular Schwannomas. CANCER MEDICINE, Vol. 15(1): e71480

Byoung Seok Ye, So Hee Park, Seun Jeon, Sungwoo Kang, Se Hoon Kim, Won Seok Chang. (2025). Degenerative pathologies on cortical biopsy, dopaminergic depletion, and shunt efficacy in iNPH. ALZHEIMERS & DEMENTIA, Vol.21(12): e70974

Jihwan Yoo, In-Ho Jung, Won Seok Chang, Hyun Ho Jung, Hun Ho Park, Ju Hyung Moon, Eui Hyun Kim, Seok-Gu Kang, Jong Hee Chang. (2025). Neoadjuvant gamma knife surgery for metastatic brain tumor: clinical use and impact on leptomeningeal seeding. JOURNAL OF NEURO-ONCOLOGY, Vol.176(1): 100

Junhyung Kim, Seung Woo Hong, Phuong Duy Dao, Jinu Rim, Jung Woo Yu, Ara Ko, Hoon-Chul Kang, Kyoung Heo, Heung Dong Kim, Jong Hee Chang, Won Seok Chang. (2025). Safety and efficacy of stereoelectroencephalography using a novel robot based on the center-of-arc principle in patients with medically refractory epilepsy. JOURNAL OF NEUROSURGERY, Vol.144(2): 273-281

Jaewoo Shin, Jin-Kyoung Shim, Chanho Kong, Younghee Seo, Sangheon Han, Seok-Gu Kang, Won Seok Chang. (2025). Focused ultrasound-mediated temozolomide delivery into intact blood-brain barrier tissue improves survival in patient-derived xenograft model of glioblastoma. FLUIDS AND BARRIERS OF THE CNS, Vol.22(1): 87

Junhyung Kim, Jung Woo Yu, Jinu Rim, Won Seok Chang, Hyun ho Jung. (2025). Intraoperative computed tomography-guided neuronavigation for radiofrequency rhizotomy in trigeminal neuralgia: optimizing cannulation trajectories for individual anatomy. PAIN MEDICINE, Vol.27(1): 62-67

Jagyeong Goo, Jun Seo Lee, Junwon Park, Seong Ik Jeon, Jeongrae Kim, Wan Su Yun, Nayeon Shim, Yujeong Moon, Sunejeong Song, Jinseong Kim, Hanhee Cho, Ju Yeon Jeong, Ju Seung Lee, Sangheon Han, Hyeon-Ju Lee, Won-Gun Koh, Won Seok Chang, Tae-Il Kim, Kwangmeyung Kim. (2025). Dual Delivery of Light/Prodrug Nanoparticles Using Tumor-Implantable Micro Light-Emitting Diode on an Optofluidic System for Combinational Glioma Treatment. ACS NANO, Vol.19(18): 17393-17409

Jeongyoon Shin, Wonsik Yang, Jungmin Seo, Won Seok Chang, Heung Dong Kim, Se Hee Kim. (2025). Intracranial Disease-Region Composite-Interpretation Technology for Enhanced Source Localization in Pediatric Epilepsy Surgery. IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING, Vol.33: 34-45

Junwon Park, Young Cheol Na, Jihyeon Lee, Younghee Seo, Hojin Kim, Sangheon Han Byeong-Wook Song, Won Seok Chang. (2025). Role of P2X7 receptor during focused ultrasound induced blood brain barrier modulation. Scientific Reports, Vol.15(1): 965

Tae Young Park, Heekyung Koh, Wonhye Lee, So Hee Park, Won Seok Chang, Hyungmin Kim. (2023). Real-Time Acoustic Simulation Framework for tFUS: A Feasibility Study Using Navigation System. Neuroimage, Vol.282: 120411

Jay Jiyoung Kwak, Kwang Seob Lee, Junwon Lee, Yong Joon Kim, Eun Young Choi, Suk Ho Byeon, Won Seok Chang, Yu Ri Kim, Jin Seok Kim, Saeam Shin, Seung-Tae Lee, Sung Soo Kim, Christopher Suengkyu Lee. (2023) Next-Generation Sequencing of Vitreoretinal Lymphoma by Vitreous Liquid Biopsy: Diagnostic Potential and Genotype/Phenotype Correlation. Investigative ophthalmology & visual science, Vol.64(27)

Junhyung Kim, Seung Woo Hong, Hyun Ho Jung, Yong Bae Kim, Joonho Chung, Won Seok Chang, Keun Young Park. (2023). Stereotactic radiosurgery for noncavernous sinus dural arteriovenous fistulas: treatment outcomes and their predictors. Journal of Neurosurgery, Vol.140(5): 1389-1398

Ji Young Park, Junwon Park, Jiwon Baek, Jin Woo Chang, Young Goo Kim, Won Seok Chang. (2023). Long-term results on the suppression of secondary brain injury by early administered low-dose baclofen in a traumatic brain injury mouse model. Scientific reports, Vol.13(1): 18563

Min Jeoung Kim, Seung Woo Hong, Dong Joon Kim, Byung Moon Kim, Young Bae Kim, Won Seok Chang, Keun Young Park. (2023). Efficacy and safety of stereotactic radiosurgery versus endovascular treatment for symptomatic cavernous sinus dural arteriovenous fistula without ophthalmological emergency: a single-center 10-year experience. Journal of Neurosurgery, Vol.139(1): 139-149

Sayemul Islam, Eungyoul Oh, Chaerin Jun, Jungkwun Kim, Won Seok Chang, Seunghyun Song, Albert Kim. (2023). Omni-Directional Ultrasonic Powering via Platonic Solid Receiver for mm-Scale Implantable Devices. ACS Materials Letters, Vol.5(7): 1876-1885

Chanho Kong, Ji Woong Ahn, Sohyun Kim, Ji Young Park, Young Cheol Na, Jin Woo Chang, Seungsoo Chung, Won Seok Chang. (2023). Long-lasting restoration of memory function and hippocampal synaptic plasticity by focused ultrasound in Alzheimer's disease. Brain stimulation, Vol.16(3) : 857-866

Myung Ji Kim, Hyun Ho Jung, Yong Bae Kim, Jong Hee Chang, Jin Woo Chang, Keun Young Park, Won Seok Chang. (2023). Comparison of Single-Session, Neoadjuvant, and Adjuvant Embolization Gamma Knife Radiosurgery for Arteriovenous Malformation. Neurosurgery, Vol.92(5) : 986-997

Jhin Goo Chang, Do-Won Kim, Hyun Ho Jung, Won Seok Chang, Chan-Hyung Kim, Se Joo Kim, Jin Woo Chang. (2023). Evaluation of changes in neural oscillation after bilateral capsulotomy in treatment refractory obsessive-compulsive disorder using magnetoencephalogram. Asian Journal of Psychiatry, Vol.52 : 103473

Junwon Park, Chanho Kong, Jaewoo Shin, Ji Young Park, Young Cheol Na, Seung Hee Han, Jin Woo Chang, Seung Hyun Song, Won Seok Chang. (2023). Combined Effects of Focused Ultrasound and Photodynamic Treatment for Malignant Brain Tumors Using C6 Glioma Rat Model. Yonsei Medical Journal, Vol.64(4) : 233-242

Younghee Seo, Sangheon Han, Byeong-Wook Song, Jin Woo Chang, Young Cheol Na, Won Seok Chang. (2023). Endogenous Neural Stem Cell Activation after Low-Intensity Focused Ultrasound-Induced Blood–Brain Barrier Modulation. International Journal of Moecular Sciences, Vol.24(6): 5712

Kyung Won Chang, Seung Woo Hong, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang. (2023). Characteristics of Focused Ultrasound Mediated Blood-Brain Barrier Opening in Magnetic Resonance Images. Journal of Korean Neurosurgical Society, Vol.66(2): 172-182

Ja Hye Kim, Ji-Hyung Park, Junehawk Lee, Jung Woo Park, Hyun Jung Kim, Won Seok Chang, Dong-Seok Kim, Young Seok Ju, Eleonora Aronica, Jeong Ho Lee. (2023). Ultra-Low Level Somatic Mutations and Structural Variations in Focal Cortical Dysplasia Type II. Annals of Neuorology, Vol.93(6): 1082-1093

Chanho Kong, Won Seok Chang. (2023). Preclinical Research on Focused Ultrasound-Mediated Blood–Brain Barrier Opening for Neurological Disorders: A Reviews. Neurology International, Vol.15(1): 285-300

Min Jeoung Kim, Seung Woo Hong, Dong Joon Kim, Byung Moon Kim, Yong Bae Kim, Won Seok Chang, Keun Yong Park. (2022). Efficacy and safety of stereotactic radiosurgery versus endovascular treatment for symptomatic cavernous sinus dural arteriovenous fistula without ophthalmological emergency: a single-center 10-year experience. Journal of Neurosurgery, Vol.139(1): 139-149

Chanho Kong, Eun-Jeong Yang, Jaewoo Shin, Junwon Park, Si-Hyun Kim, Seong-Wook Park, Won Seok Chang, Chang-Han Lee, Hyunju Kim, Hye-Sun Kim, Jin Woo Chang. (2022). Enhanced delivery of a low dose of aducanumab via FUS in 5×FAD mice, an AD model. Translational Neurodegeneration, Vol.11(1): 57

In-Ho Jung, Kyung Won Chang, So Hee Park, Hyun Ho Jung, Jong Hee Chang, Jin Woo Chang, Won Seok Chang. (2022). Pseudoprogression and peritumoral edema due to intratumoral necrosis after Gamma knife radiosurgery for meningioma. Scientific reports, Vol.12(1): 13663

Chongwon Pae, Myung Ji Kim, Won Seok Chang, Hyun Ho Jung, Kyung Won Chang, Jinseok Eo, Hae-Jeong Park, Jin Woo Chang. (2022). Differences in intrinsic functional networks in patients with essential tremor who had good and poor long-term responses after thalamotomy performed using MR-guided ultrasound. Journal of Neurosurgery, Vol.138(2): 318-328

So Hee Park, Dong Min Choi, In-Ho Jung, Kyung Won Chang, Myung Ji Kim, Hyun Ho Jung, Jin Woo Chang, Hwiyoung Kim, Won Seok Chang. (2022). Clinical application of deep learning-based synthetic CT from real MRI to improve dose planning accuracy in Gamma Knife radiosurgery: a proof of concept study. Biomedical Engineering Letters, Vol.12(4): 359-367

Young Goo Kim, Chang Kyu Park, Na Young Jung, Hyun Ho Jung, Jong Hee Chang, Jin Woo Chang, Won Seok Chang. (2022). Early-onset adverse events after stereotactic radiosurgery for jugular foramen schwannoma: a mid-term follow-up single-center review of 46 cases. Radiation Oncology, Vol.17(1): 89

So Hee Park, In-Ho Jung, Kyung Won Chang, Maeng Keun Oh, Jin Woo Chang, Se Hee Kim, Hoon-Chul Kang, Heung Dong Kim, Won Seok Chang. (2022). Epidural grid, a new methodology of invasive intracranial EEG monitoring: A technical note and experience of a single center. Epilepsy Research, Vol.182: 106912

In-Ho Jung, Kyung Won Chang, So Hee Park, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang. (2022). Complications After Deep Brain Stimulation: A 21-Year Experience in 426 Patients. Frontiers in Aging Neuroscience, Vol.14: 819730

Kyoung Won Chang, Myung Ji Kim, So Hee Park, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang. (2022). Dual Pallidal and Thalamic Deep Brain Stimulation for Complex Ipsilateral Dystonia. Yonsei Medical Journal, Vol.63(2): 166-172

Myung Ji Kim, So Hee Park, Kyung Won Chang, Yuhee Kim, Jing Gao, Maya Kovalevsky, Itay Rachmilevitch, Eyal Zadicario, Won Weok Chang, Hyun Ho Jung, Jin Woo Chang. (2021). Technical and operative factors affecting magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor: experience from 250 treatments. Journal of neurosurgery, Vol.135(6): 1780-1788

Chanho Kong, So Hee Park, Jaewoo Shin, Hee Gyu Baek, Juyoung Park, Young Cheol Na, Won Seok Chang, Jin Woo Chang. (2021). Factors Associated with Energy Efficiency of Focused Ultrasound Through the Skull: A Study of 3D-Printed Skull Phantoms and Its Comparison with Clinical Experiences. Frontiers in Bioengineering and Biotechnology, Vol.9: 783048

So Hee Park, Kyungwon Baik, Seun Jeon, Won Seok Chang, Byuoung Seok Ye, Jin Woo Chang. (2021). Extensive frontal focused ultrasound mediated blood-brain barrier opening for the treatment of Alzheimer's disease: a proof-of-concept study. Translational neurodegeneration, Vol.10(44)

In-Ho Jung, Kyung Won Chang, So Hee Park, Ju Hyung Moon, Eui Hyun Kim, Hyun Ho Jung, Seok-Gu Kang, Jong Hee Chang, Jin Woo Chang, Won Seok Chang. (2021). Stereotactic biopsy for adult brainstem lesions: A surgical approach and its diagnostic value according to the 2016 World Health Organization Classification. Cancer Medicine, Vol.10(21): 7514-7524

Myung Ji Kim, Kyung Won Chang, So Hee Park, Won Seok Chang, Jong Hee Chang, Jin Woo Chang, Hyun Ho Jung. (2021). Predictive Factors of Radiation-Induced Changes Following Single-Session Gamma Knife Radiosurgery for Arteriovenous Malformations. Journal of Clinical Medicine, Vol.10(10): 2186

Jaehyuk Kim, Jaewoo Shin, Chanho Kong, Sung-Ho Lee, Won Seok Chang, Seung Hee Han. (2021). The synergistic effect of focused ultrasound and biophotonics to overcome the barrier of light transmittance in biological tissue. Photodiagnosis and Photodynamic Therapy, Vol.33: 102713

Hun Ho Park, So Hee Park, Hyeong-Choel Oh, Hyun-Ho Jung, Jong Hee Chang, Kyu-Sung Lee, Won Seok Chang, Chang-Ki Hong. (2021). The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas. Scientific reports, Vol.11(1): 4665

Kyung Won Chang, Itay Rachmilevitch, Won Seok Chang, Hyun-Ho Jung, Eyal Zadicario, Oleg Prus, Jin Woo Chang. (2021). Safety and Efficacy of Magnetic Resonance-Guided Focused Ultrasound Surgery With Autofocusing Echo Imaging. Frontiers in Neuroscience, Vol.14: 592763

Hun Ho Park, Woo Hyun Kim, Hyun-Ho Jung, jong Hee Chang, Kyu-Sung Lee, Won Seok Chang, Chang-Ki Hong. (2020). Radiosurgery vs. microsurgery for newly diagnosed, small petroclival meningiomas with trigeminal neuralgia. Neurosurgical Review, Vol.43(6): 1631-1640

Jhin-Goo Chang, Hyun-Ho Jung, Se Joo Kim, Won Seok Chang, Na Young Jung, Chan-Hyung Kim, Jin Woo Chang. (2020). Bilateral thermal capsulotomy with magnetic resonance-guided focused ultrasound for patients with treatment-resistant depression: A proof-of-concept study. Bipolar Disorders, Vol.22(7): 771-774

Jin Mo Cho, Kyoung Su Sung, In Ho Jung, Won Seok Chang, Hyun Ho Jung, Jong Hee Chang. (2020). Temporal Volume Change of Cavernous Sinus Cavernous Hemangiomas after Gamma Knife Surgery. Yonsei Medical Journal, Vol.61(11): 976-980

Myung Ji Kim, So Hee Park, Kyoung Heo, Jin Woo Chang, Joon Il Kim, Won Seok Chang. (2020). Functional Neural Changes after Low-Frequency Bilateral Globus Pallidus Internus Deep Brain Stimulation for Post-Hypoxic Cortical Myoclonus: Voxel-Based Subtraction Analysis of Serial Positron Emission. Brain Sciences, Vol.10(10): 730

So Hee Park, Myung Ji Kim, Hyun Ho Jung, Won Seok Chang, Hyun Seok Choi, Itay Rachmilevitch, Eyal Zadicario, Jin Woo Chang. (2020). One-Year Outcome of Multiple Blood–Brain Barrier Disruptions With Temozolomide for the Treatment of Glioblastoma. Frontiers in Oncology, Vol.10: 1663

Myung Ji Kim, So Hee Park, Keun Young Park, Hyun Ho Jung, Jong Hee Chang, Jin Woo Chang, Jae Whan Lee, Won Seok Chang. (2020). Gamma knife radiosurgery followed by flow-reductive embolization for ruptured arteriovenous malformations. Journal of Clinical Medicine, Vol.9(5): 1318

Jihyeon Lee, Won Seok Chang, Jaewoo Shin, Younghee Seo, Chanho Kong, Byeong-Woo Song, Young Cheol Na, Bong Soo Kim, Jin Woo Chang. (2020). Non-invasively enhanced intracranial transplantation of mesenchymal stem cells using focused ultrasound mediated by overexpression of cell-adhesion molecules. Stem Cell Research, Vol.43: 101726

Won Seok Chang, Midori Nakajima, Ayako Ochi, Elysa Widjaja, James T Rutka, Ivanna Yau, Shiro Baba, Hiroshi Otsubo. (2020). Detection of epileptogenic focus using advanced dynamic statistical parametric mapping with magnetoencephalography in a patient with MRI-negative focal cortical dysplasia type IIB. Journal of Neurosurgery-Pediatrics, Vol.25(1): 78-82

Kyu Seon Chung, Won Seok Chang, Jong Hee Chang, Sung Chul Lee, jin Woo Chang, Yong Gou Park, Hyun Ho Jung. (2020). Gamma knife radiosurgery for choroidal hemangioma: a single-institute series. World Neurosurgery, Vol.133: e129-e134

Chang Kyu Park, Na Young Jung, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang. (2019). Gamma Knife Radiosurgery for Postoperative Remnant Meningioma: Analysis of Recurrence Factors According to World Health Organization Grade. World Neurosurgery, 132:e339-e402

Kyoo Ho Cho, Su Jung Hwang, Bong Soo Kim, Kyoung Heo, Won Seok Chang, Jin Woo Chang. (2019). Regional Connectivity Changes According to Seizure Outcome of Temporal Epilepsy Surgery: A Magnetoencephalography Study. Biomedical Journal of Scientific & Technical Research , Vol.22(3): 16657-16665

Young Goo Kim, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang. (2019). The long-term effects of microvascular decompression on social phobia and health-related quality of life in patients with hemifacial spasm: a 3-year prospective study. Acta Neurochirurgica, Vol.161(10): 2035-2042

Minji Chae, Seungbeen Hong, Na Young Jung, Won Seok Chang, Sung-Rae Cho. (2019). Outcomes of Intrathecal Baclofen Therapy Compared With Deep Brain Stimulation in a Patient With Dystonic Cerebral Palsy: A Case Report. Annals of Rehabilitation Medicine, Vol.43(3): 335-340

Chang Kyu Park, Su Jeong Hwang, Na Young Jung, Won Seok Chang, Hyun Ho Jung Jin Woo Chang. (2019). Magnetoencephalography as a Prognostic Tool in Patients with Medically Intractable Temporal Lobe Epilepsy. World Neurosurgery, Vol.123:e753-e759

Kwanhwi Ko, Hajun Yoo, Sangheon Han, Won Seok Chang, Donhyun Kim. (2024). Surface-enhanced Raman spectroscopy with single cell manipulation by microfluidic dielectrophoresis. The Analyst, 149, 5649-5656

Jeongrae Kim, Hin Kiu Lee, Junwon Park, Seong Ik Jeon, Il Seong Lee, Wan Su Yun, Yujeong Moon, Jiwoong Choi, Man Kyu Shim, Jinseong Kim,Hanhee Cho, Nayeon Shim, Namcheol Hwang, Gyan Raj Koirala, Minjun Gwak, Sangheon Han, Dong-Hwee Kim, Won Seok Chang, Tae-il Kim, Kwangmeyung Kim. (2024). Implantable MicroLED-Mediated Chemo-Photodynamic Combination Therapy for Glioma Treatment. Advanced Functional Materials, Vol.34(30): 2316386

Jiwon Baek, Younghee Seo, Bong Soo Kim, Young Cheol Na, Won Seok Chang. (2024). Changes in theta and gamma oscillations of the medial prefrontal cortex following hippocampal-focused ultrasound stimulation. Neurofunction, Vol.20(1): 21-27

Jun Hyeong Park, Jinu Rim, Jun hyung Kim, Hyun Ho Jung, Jung Woo Yu, Won Seok Chang. (2024). Stereotactic radiosurgery for pituitary adenoma. Neurofunction, Vol.20(1): 9-14

Younghoon Park, Jaewoo Shin, Junwon Park, Seulbi Kim, Ji Hun Park, Jaeheung Kim, Chang Seok Kim, Jin Woo Chang, Carol Schuurmans, Isabelle Aubert, Won Seok Chang, Kyungsik Eom. (2024). Focused Ultrasound as a Novel Non-Invasive Method for the Delivery of Gold Nanoparticles to Retinal Ganglion Cells. Translational Vision Science & Technology, Vol.13(5)

Younghee Seo, Kyung Won Chang, Jihyeon Lee, Chanho Kong, Jaewoo Shin, Jin Woo Chang, Young Cheol Na, Won Seok Chang. (2024). Optimal timing for drug delivery into the hippocampus by focused ultrasound: A comparison of hydrophilic and lipophilic compounds. Heliyon, Vol.10(8): e29480

Kyung Min Kim, Tae Kwon Lee, Su Min, Lee, Won Seok Chang, Su Ji Lee, Jihye Hwang, Sung-Rae Cho. (2024). Case report: Intrathecal baclofen therapy improved gait pattern in a stroke patient with spastic dystonia. Frontiers in Neurology, Vol.15

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