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NSIM lab

Publications

Junwon Park, Young Cheol Na, Jihyeon Lee, Younghee Seo, Hojin Kim, Sangheon Han Byeong-Wook Song, Won Seok Chang. (2025). Role of P2X7 receptor during focused ultrasound induced blood brain barrier modulation. Scientific Reports, 15, 965

Jeongyoon Shin, Wonsik Yang, Jungmin Seo, Won Seok Chang, Heung Dong Kim, Se Hee Kim. (2024). Intracranial Disease-Region Composite- Interpretation Technology for Enhanced Source Localization in Pediatric Epilepsy Surgery. IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING, Vol.33: 34-45

Kwanhwi Ko, Hajun Yoo, Sangheon Han, Won Seok Chang, Donhyun Kim. (2024). Surface-enhanced Raman spectroscopy with single cell manipulation by microfluidic dielectrophoresis. The Analyst, 149, 5649-5656

Jeongrae Kim, Hin Kiu Lee, Junwon Park, Seong Ik Jeon, Il Seong Lee, Wan Su Yun, Yujeong Moon, Jiwoong Choi, Man Kyu Shim, Jinseong Kim,Hanhee Cho, Nayeon Shim, Namcheol Hwang, Gyan Raj Koirala, Minjun Gwak, Sangheon Han, Dong-Hwee Kim, Won Seok Chang, Tae-il Kim, Kwangmeyung Kim. (2024). Implantable MicroLED-Mediated Chemo-Photodynamic Combination Therapy for Glioma Treatment. Advanced Functional Materials, Vol.34(30): 2316386

Jiwon Baek, Younghee Seo, Bong Soo Kim, Young Cheol Na, Won Seok Chang. (2024). Changes in theta and gamma oscillations of the medial prefrontal cortex following hippocampal-focused ultrasound stimulation. Neurofunction, Vol.20(1): 21-27

Jun Hyeong Park, Jinu Rim, Jun hyung Kim, Hyun Ho Jung, Jung Woo Yu, Won Seok Chang. (2024). Stereotactic radiosurgery for pituitary adenoma. Neurofunction, Vol.20(1): 9-14

Younghoon Park, Jaewoo Shin, Junwon Park, Seulbi Kim, Ji Hun Park, Jaeheung Kim, Chang Seok Kim, Jin Woo Chang, Carol Schuurmans, Isabelle Aubert, Won Seok Chang, Kyungsik Eom. (2024). Focused Ultrasound as a Novel Non-Invasive Method for the Delivery of Gold Nanoparticles to Retinal Ganglion Cells. Translational Vision Science & Technology, Vol.13(5)

Younghee Seo, Kyung Won Chang, Jihyeon Lee, Chanho Kong, Jaewoo Shin, Jin Woo Chang, Young Cheol Na, Won Seok Chang. (2024). Optimal timing for drug delivery into the hippocampus by focused ultrasound: A comparison of hydrophilic and lipophilic compounds. Heliyon, Vol.10(8): e29480

Kyung Min Kim, Tae Kwon Lee, Su Min, Lee, Won Seok Chang, Su Ji Lee, Jihye Hwang, Sung-Rae Cho. (2024). Case report: Intrathecal baclofen therapy improved gait pattern in a stroke patient with spastic dystonia. Frontiers in Neurology, Vol.15

Min Jeoung Kim, Seung Woo Hong, Dong Joon Kim, Byung Moon Kim, Yong Bae Kim, Won Seok Chang, Keun Yong Park. (2022). Efficacy and safety of stereotactic radiosurgery versus endovascular treatment for symptomatic cavernous sinus dural arteriovenous fistula without ophthalmological emergency: a single-center 10-year experience. Journal of Neurosurgery, Vol.139(1): 139-149

Chanho Kong, Eun-Jeong Yang, Jaewoo Shin, Junwon Park, Si-Hyun Kim, Seong-Wook Park, Won Seok Chang, Chang-Han Lee, Hyunju Kim, Hye-Sun Kim, Jin Woo Chang. (2022). Enhanced delivery of a low dose of aducanumab via FUS in 5×FAD mice, an AD model. Translational Neurodegeneration, Vol.11(1): 57

In-Ho Jung, Kyung Won Chang, So Hee Park, Hyun Ho Jung, Jong Hee Chang, Jin Woo Chang, Won Seok Chang. (2022). Pseudoprogression and peritumoral edema due to intratumoral necrosis after Gamma knife radiosurgery for meningioma. Scientific reports, Vol.12(1): 13663

Chongwon Pae, Myung Ji Kim, Won Seok Chang, Hyun Ho Jung, Kyung Won Chang, Jinseok Eo, Hae-Jeong Park, Jin Woo Chang. (2022). Differences in intrinsic functional networks in patients with essential tremor who had good and poor long-term responses after thalamotomy performed using MR-guided ultrasound. Journal of Neurosurgery, Vol.138(2): 318-328

So Hee Park, Dong Min Choi, In-Ho Jung, Kyung Won Chang, Myung Ji Kim, Hyun Ho Jung, Jin Woo Chang, Hwiyoung Kim, Won Seok Chang. (2022). Clinical application of deep learning-based synthetic CT from real MRI to improve dose planning accuracy in Gamma Knife radiosurgery: a proof of concept study. Biomedical Engineering Letters, Vol.12(4): 359-367

Young Goo Kim, Chang Kyu Park, Na Young Jung, Hyun Ho Jung, Jong Hee Chang, Jin Woo Chang, Won Seok Chang. (2022). Early-onset adverse events after stereotactic radiosurgery for jugular foramen schwannoma: a mid-term follow-up single-center review of 46 cases. Radiation Oncology, Vol.17(1): 89

So Hee Park, In-Ho Jung, Kyung Won Chang, Maeng Keun Oh, Jin Woo Chang, Se Hee Kim, Hoon-Chul Kang, Heung Dong Kim, Won Seok Chang. (2022). Epidural grid, a new methodology of invasive intracranial EEG monitoring: A technical note and experience of a single center. Epilepsy Research, Vol.182: 106912

In-Ho Jung, Kyung Won Chang, So Hee Park, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang. (2022). Complications After Deep Brain Stimulation: A 21-Year Experience in 426 Patients. Frontiers in Aging Neuroscience, Vol.14: 819730

Kyoung Won Chang, Myung Ji Kim, So Hee Park, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang. (2022). Dual Pallidal and Thalamic Deep Brain Stimulation for Complex Ipsilateral Dystonia. Yonsei Medical Journal, Vol.63(2): 166-172

Myung Ji Kim, So Hee Park, Kyung Won Chang, Yuhee Kim, Jing Gao, Maya Kovalevsky, Itay Rachmilevitch, Eyal Zadicario, Won Weok Chang, Hyun Ho Jung, Jin Woo Chang. (2021). Technical and operative factors affecting magnetic resonance imaging-guided focused ultrasound thalamotomy for essential tremor: experience from 250 treatments. Journal of neurosurgery, Vol.135(6): 1780-1788

Chanho Kong, So Hee Park, Jaewoo Shin, Hee Gyu Baek, Juyoung Park, Young Cheol Na, Won Seok Chang, Jin Woo Chang. (2021). Factors Associated with Energy Efficiency of Focused Ultrasound Through the Skull: A Study of 3D-Printed Skull Phantoms and Its Comparison with Clinical Experiences. Frontiers in Bioengineering and Biotechnology, Vol.9: 783048

So Hee Park, Kyungwon Baik, Seun Jeon, Won Seok Chang, Byuoung Seok Ye, Jin Woo Chang. (2021). Extensive frontal focused ultrasound mediated blood-brain barrier opening for the treatment of Alzheimer's disease: a proof-of-concept study. Translational neurodegeneration, Vol.10(44)

In-Ho Jung, Kyung Won Chang, So Hee Park, Ju Hyung Moon, Eui Hyun Kim, Hyun Ho Jung, Seok-Gu Kang, Jong Hee Chang, Jin Woo Chang, Won Seok Chang. (2021). Stereotactic biopsy for adult brainstem lesions: A surgical approach and its diagnostic value according to the 2016 World Health Organization Classification. Cancer Medicine, Vol.10(21): 7514-7524

Myung Ji Kim, Kyung Won Chang, So Hee Park, Won Seok Chang, Jong Hee Chang, Jin Woo Chang, Hyun Ho Jung. (2021). Predictive Factors of Radiation-Induced Changes Following Single-Session Gamma Knife Radiosurgery for Arteriovenous Malformations. Journal of Clinical Medicine, Vol.10(10): 2186

Jaehyuk Kim, Jaewoo Shin, Chanho Kong, Sung-Ho Lee, Won Seok Chang, Seung Hee Han. (2021). The synergistic effect of focused ultrasound and biophotonics to overcome the barrier of light transmittance in biological tissue. Photodiagnosis and Photodynamic Therapy, Vol.33: 102713

Hun Ho Park, So Hee Park, Hyeong-Choel Oh, Hyun-Ho Jung, Jong Hee Chang, Kyu-Sung Lee, Won Seok Chang, Chang-Ki Hong. (2021). The behavior of residual tumors following incomplete surgical resection for vestibular schwannomas. Scientific reports, Vol.11(1): 4665

Kyung Won Chang, Itay Rachmilevitch, Won Seok Chang, Hyun-Ho Jung, Eyal Zadicario, Oleg Prus, Jin Woo Chang. (2021). Safety and Efficacy of Magnetic Resonance-Guided Focused Ultrasound Surgery With Autofocusing Echo Imaging. Frontiers in Neuroscience, Vol.14: 592763

Hun Ho Park, Woo Hyun Kim, Hyun-Ho Jung, jong Hee Chang, Kyu-Sung Lee, Won Seok Chang, Chang-Ki Hong. (2020). Radiosurgery vs. microsurgery for newly diagnosed, small petroclival meningiomas with trigeminal neuralgia. Neurosurgical Review, Vol.43(6): 1631-1640

Jhin-Goo Chang, Hyun-Ho Jung, Se Joo Kim, Won Seok Chang, Na Young Jung, Chan-Hyung Kim, Jin Woo Chang. (2020). Bilateral thermal capsulotomy with magnetic resonance-guided focused ultrasound for patients with treatment-resistant depression: A proof-of-concept study. Bipolar Disorders, Vol.22(7): 771-774

Jin Mo Cho, Kyoung Su Sung, In Ho Jung, Won Seok Chang, Hyun Ho Jung, Jong Hee Chang. (2020). Temporal Volume Change of Cavernous Sinus Cavernous Hemangiomas after Gamma Knife Surgery. Yonsei Medical Journal, Vol.61(11): 976-980

Myung Ji Kim, So Hee Park, Kyoung Heo, Jin Woo Chang, Joon Il Kim, Won Seok Chang. (2020). Functional Neural Changes after Low-Frequency Bilateral Globus Pallidus Internus Deep Brain Stimulation for Post-Hypoxic Cortical Myoclonus: Voxel-Based Subtraction Analysis of Serial Positron Emission. Brain Sciences, Vol.10(10): 730

So Hee Park, Myung Ji Kim, Hyun Ho Jung, Won Seok Chang, Hyun Seok Choi, Itay Rachmilevitch, Eyal Zadicario, Jin Woo Chang. (2020). One-Year Outcome of Multiple Blood–Brain Barrier Disruptions With Temozolomide for the Treatment of Glioblastoma. Frontiers in Oncology, Vol.10: 1663

Myung Ji Kim, So Hee Park, Keun Young Park, Hyun Ho Jung, Jong Hee Chang, Jin Woo Chang, Jae Whan Lee, Won Seok Chang. (2020). Gamma knife radiosurgery followed by flow-reductive embolization for ruptured arteriovenous malformations. Journal of Clinical Medicine, Vol.9(5): 1318

Jihyeon Lee, Won Seok Chang, Jaewoo Shin, Younghee Seo, Chanho Kong, Byeong-Woo Song, Young Cheol Na, Bong Soo Kim, Jin Woo Chang. (2020). Non-invasively enhanced intracranial transplantation of mesenchymal stem cells using focused ultrasound mediated by overexpression of cell-adhesion molecules. Stem Cell Research, Vol.43: 101726

Won Seok Chang, Midori Nakajima, Ayako Ochi, Elysa Widjaja, James T Rutka, Ivanna Yau, Shiro Baba, Hiroshi Otsubo. (2020). Detection of epileptogenic focus using advanced dynamic statistical parametric mapping with magnetoencephalography in a patient with MRI-negative focal cortical dysplasia type IIB. Journal of Neurosurgery-Pediatrics, Vol.25(1): 78-82

Kyu Seon Chung, Won Seok Chang, Jong Hee Chang, Sung Chul Lee, jin Woo Chang, Yong Gou Park, Hyun Ho Jung. (2020). Gamma knife radiosurgery for choroidal hemangioma: a single-institute series. World Neurosurgery, Vol.133: e129-e134

Chang Kyu Park, Na Young Jung, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang. (2019). Gamma Knife Radiosurgery for Postoperative Remnant Meningioma: Analysis of Recurrence Factors According to World Health Organization Grade. World Neurosurgery, 132:e339-e402

Kyoo Ho Cho, Su Jung Hwang, Bong Soo Kim, Kyoung Heo, Won Seok Chang, Jin Woo Chang. (2019). Regional Connectivity Changes According to Seizure Outcome of Temporal Epilepsy Surgery: A Magnetoencephalography Study. Biomedical Journal of Scientific & Technical Research , Vol.22(3): 16657-16665

Young Goo Kim, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang. (2019). The long-term effects of microvascular decompression on social phobia and health-related quality of life in patients with hemifacial spasm: a 3-year prospective study. Acta Neurochirurgica, Vol.161(10): 2035-2042

Minji Chae, Seungbeen Hong, Na Young Jung, Won Seok Chang, Sung-Rae Cho. (2019). Outcomes of Intrathecal Baclofen Therapy Compared With Deep Brain Stimulation in a Patient With Dystonic Cerebral Palsy: A Case Report. Annals of Rehabilitation Medicine, Vol.43(3): 335-340

Chang Kyu Park, Su Jeong Hwang, Na Young Jung, Won Seok Chang, Hyun Ho Jung Jin Woo Chang. (2019). Magnetoencephalography as a Prognostic Tool in Patients with Medically Intractable Temporal Lobe Epilepsy. World Neurosurgery, Vol.123:e753-e759

Kyoung Su Sung, Ju Hyung Moon, Eui Hyun Kim, Seok-Gu Kang, Se Hoon Kim, Chang-Ok Suh, Sun Ho Kim, Kyu-Sung Lee, Won Seok Chang, Jong Hee Chang. (2018). Solitary fibrous tumor/hemangiopericytoma: treatment results based on the 2016 WHO classification. Journal of Neurosurgery, Vol.1;1-8

Ji Woong oh, Kyoung Su Sung, Ju Hyung Moon, Eui Hyun Kim, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang, Yong Gou Park, Sun Ho Kim, Jong Hee Chang. (2018). Hypopituitarism after Gamma Knife surgery for postoperative nonfunctioning pituitary adenoma. Journal of Neurosurgery, Vol.1;129(Suppl1):47-54

Se Joo Kim, Daeyoung Roh, Hyun Ho Jung, Won Seok Chang, Chah-hyung Kim, Jin Woo Chang. (2018). A study of novel bilateral thermal capsulotomy with focused ultrasound for treatment-refractory obsessive-compulsive disorder: 2-year follow-up. Journal of Psychiatry & Neuroscience, Vol.43(5):327-337

Yoon Ha Hwang, Na Young Jung, Chang Kyu Park, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang. (2018). Factors Related to the Clinical Outcomes of Surgery for Extra-Temporal Lobe Epilepsy: Long-Term Follow-Up Results. World Neurosurgery, Vol.115:e645-e649

Hyun Ho Jung, Won Seok Chang, Se Joo Kim, Chan-Hyung Kim, Jin Woo Chang. (2018). The Potential Usefulness of Magnetic Resonance Guided Focused Ultrasound for Obsessive Compulsive Disorders. Journal of Korean Neurosurgical Society, Vol.61(4):427-433

Ji Hee Kim, Bong Soo Kim, Su Jeong Hwang, Won Seok Chang, Ki Woong Kim, Hyuk Chan Kwon, Yong Ho Lee, Jin Woo Chang. (2018). Symptom-associated change of motor-related neuromagnetic fields in a patient with multiple sclerosis: A case report. Journal of Clinical Neuroscience, Vol.50:115-122

Na Young Jung, Chang Kyu Park, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang. (2018). Effects on cognition and quality of life with unilateral magnetic resonance–guided focused ultrasound thalamotomy for essential tremor. Neurosurgical Focus, Vol.44(2):E8

Sangtae Ahn, Hohyun Cho, Moonyoung Kwon, Kiwoong Kim, Hyukchan Kwon, Bong Soo Kim, Won Seok Chang, Jin Woo Chang, Sung Chan Jun. (2018). Interbrain phase synchronization during turn-taking verbal interaction-a hyperscanning study using simultaneous EEG/MEG. Human Brain Mapping, Vol.39(1):171-188

Tae Young Park, Heekyung Koh, Wonhye Lee, So Hee Park, Won Seok Chang, Hyungmin Kim. (2023). Real-Time Acoustic Simulation Framework for tFUS: A Feasibility Study Using Navigation System. Neuroimage, Vol.282: 120411

Jay Jiyoung Kwak, Kwang Seob Lee, Junwon Lee, Yong Joon Kim, Eun Young Choi, Suk Ho Byeon, Won Seok Chang, Yu Ri Kim, Jin Seok Kim, Saeam Shin, Seung-Tae Lee, Sung Soo Kim, Christopher Suengkyu Lee. (2023) Next-Generation Sequencing of Vitreoretinal Lymphoma by Vitreous Liquid Biopsy: Diagnostic Potential and Genotype/Phenotype Correlation. Investigative ophthalmology & visual science, Vol.64(27)

Junhyung Kim, Seung Woo Hong, Hyun Ho Jung, Yong Bae Kim, Joonho Chung, Won Seok Chang, Keun Young Park. (2023). Stereotactic radiosurgery for noncavernous sinus dural arteriovenous fistulas: treatment outcomes and their predictors. Journal of Neurosurgery, Vol.140(5): 1389-1398

Ji Young Park, Junwon Park, Jiwon Baek, Jin Woo Chang, Young Goo Kim, Won Seok Chang. (2023). Long-term results on the suppression of secondary brain injury by early administered low-dose baclofen in a traumatic brain injury mouse model. Scientific reports, Vol.13(1): 18563

Min Jeoung Kim, Seung Woo Hong, Dong Joon Kim, Byung Moon Kim, Young Bae Kim, Won Seok Chang, Keun Young Park. (2023). Efficacy and safety of stereotactic radiosurgery versus endovascular treatment for symptomatic cavernous sinus dural arteriovenous fistula without ophthalmological emergency: a single-center 10-year experience. Journal of Neurosurgery, Vol.139(1): 139-149

Sayemul Islam, Eungyoul Oh, Chaerin Jun, Jungkwun Kim, Won Seok Chang, Seunghyun Song, Albert Kim. (2023). Omni-Directional Ultrasonic Powering via Platonic Solid Receiver for mm-Scale Implantable Devices. ACS Materials Letters, Vol.5(7): 1876-1885

Chanho Kong, Ji Woong Ahn, Sohyun Kim, Ji Young Park, Young Cheol Na, Jin Woo Chang, Seungsoo Chung, Won Seok Chang. (2023). Long-lasting restoration of memory function and hippocampal synaptic plasticity by focused ultrasound in Alzheimer's disease. Brain stimulation, Vol.16(3) : 857-866

Myung Ji Kim, Hyun Ho Jung, Yong Bae Kim, Jong Hee Chang, Jin Woo Chang, Keun Young Park, Won Seok Chang. (2023). Comparison of Single-Session, Neoadjuvant, and Adjuvant Embolization Gamma Knife Radiosurgery for Arteriovenous Malformation. Neurosurgery, Vol.92(5) : 986-997

Jhin Goo Chang, Do-Won Kim, Hyun Ho Jung, Won Seok Chang, Chan-Hyung Kim, Se Joo Kim, Jin Woo Chang. (2023). Evaluation of changes in neural oscillation after bilateral capsulotomy in treatment refractory obsessive-compulsive disorder using magnetoencephalogram. Asian Journal of Psychiatry, Vol.52 : 103473

Junwon Park, Chanho Kong, Jaewoo Shin, Ji Young Park, Young Cheol Na, Seung Hee Han, Jin Woo Chang, Seung Hyun Song, Won Seok Chang. (2023). Combined Effects of Focused Ultrasound and Photodynamic Treatment for Malignant Brain Tumors Using C6 Glioma Rat Model. Yonsei Medical Journal, Vol.64(4) : 233-242

Younghee Seo, Sangheon Han, Byeong-Wook Song, Jin Woo Chang, Young Cheol Na, Won Seok Chang. (2023). Endogenous Neural Stem Cell Activation after Low-Intensity Focused Ultrasound-Induced Blood–Brain Barrier Modulation. International Journal of Moecular Sciences, Vol.24(6): 5712

Kyung Won Chang, Seung Woo Hong, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang. (2023). Characteristics of Focused Ultrasound Mediated Blood-Brain Barrier Opening in Magnetic Resonance Images. Journal of Korean Neurosurgical Society, Vol.66(2): 172-182

Ja Hye Kim, Ji-Hyung Park, Junehawk Lee, Jung Woo Park, Hyun Jung Kim, Won Seok Chang, Dong-Seok Kim, Young Seok Ju, Eleonora Aronica, Jeong Ho Lee. (2023). Ultra-Low Level Somatic Mutations and Structural Variations in Focal Cortical Dysplasia Type II. Annals of Neuorology, Vol.93(6): 1082-1093

Chanho Kong, Won Seok Chang. (2023). Preclinical Research on Focused Ultrasound-Mediated Blood–Brain Barrier Opening for Neurological Disorders: A Reviews. Neurology International, Vol.15(1): 285-300

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